Effect of an Exercise Bout in Plasma and Fecal Profile

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Prolonged Exercise session

• Registration Number: NCT04244149
• Lead Sponsor: Universidad Europea de Madrid

Brief Summary

The aim of this project is to study the effect of a bout of exercise on the metabolomic profile of plasma and feces as well as its influence on the intestinal microbiota.

Detailed Description

The practice of physical exercise has numerous health benefits, preventing the appearance and development of cardiovascular diseases and various types of cancer. Exercise causes changes in the vascular, muscular and pulmonary systems, etc. One of the benefits that can result from exercise modification of the intestinal microbiota and its metabolic profile. In order to identify the potential changes that exercise has on the intestinal microbiota and its metabolic profile, the purpose of this study is to identify changes in the plasma and fecal metabolome and in fecal microbiota associated with a bout of exercise

Study Timeline

• Study First Submitted: 2020-01-20
• Study First Submitted QC: 2020-01-24
• Study First Posted: 2020-01-28
• Study Start: 2020-02-20
• Primary Completion: 2020-03-10
• Study Completion: 2020-03-13
• Status Verified: 2020-06
• Last Update Submitted: 2020-06-18
• Last Update Posted: 2020-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• 18-45 years of age
• high physical condition (VO2 ≥ 55 ml/kg/min)
• BMI 18-25 kg/m2

Exclusion Criteria

• antibiotics intake during 3 months prior to the study,
• smoking
• nutritional complements
• ergogenic complements
• prebiotics
• probiotics
• vegetarian or vegan diet
• chronic medication
• gastrointestinal surgery
• Any diagnosed disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intervention group	Prolonged Exercise session	Participants will exert an exercise prolonged session

Primary Outcome Measures

Name	Time	Method
Plasma metabolome profile	Changes from baseline to 30 min after the exercise intervention	Abundance of blood metabolites, metabolic networks, and metabolic pathways activity
Fecal microbiota	Changes from baseline to 30 min after the exercise intervention	Abundance of gut microbial taxa, communities, and metabolic pathways activity

Trial Locations

Locations (1)

Maria del Mar Larrosa Pérez; 🇪🇸 Villaviciosa de Odon, Madrid, Spain