Exploring the Effect of Exhaustive Exercise From a Metabolomic and Metagenomic Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Plasma metabolome profile
研究概览
简要总结
The aim of this project is to study the effect of a bout of exercise on the metabolomic profile of plasma and feces as well as its influence on the intestinal microbiota.
详细描述
The practice of physical exercise has numerous health benefits, preventing the appearance and development of cardiovascular diseases and various types of cancer. Exercise causes changes in the vascular, muscular and pulmonary systems, etc. One of the benefits that can result from exercise modification of the intestinal microbiota and its metabolic profile. In order to identify the potential changes that exercise has on the intestinal microbiota and its metabolic profile, the purpose of this study is to identify changes in the plasma and fecal metabolome and in fecal microbiota associated with a bout of exercise
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-45 years of age
- •high physical condition (VO2 ≥ 55 ml/kg/min)
- •BMI 18-25 kg/m2
排除标准
- •antibiotics intake during 3 months prior to the study,
- •nutritional complements
- •ergogenic complements
- •prebiotics
- •probiotics
- •vegetarian or vegan diet
- •chronic medication
- •gastrointestinal surgery
- •Any diagnosed disease
结局指标
主要结局
Plasma metabolome profile
时间窗: Changes from baseline to 30 min after the exercise intervention
Abundance of blood metabolites, metabolic networks, and metabolic pathways activity
Fecal microbiota
时间窗: Changes from baseline to 30 min after the exercise intervention
Abundance of gut microbial taxa, communities, and metabolic pathways activity
次要结局
未报告次要终点
研究者
Mar Larrosa
Tenure Professor
Universidad Europea de Madrid