Exploring the Effect of Exhaustive Exercise From a Metabolomic and Metagenomic Approach
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Universidad Europea de Madrid
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Plasma metabolome profile
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of this project is to study the effect of a bout of exercise on the metabolomic profile of plasma and feces as well as its influence on the intestinal microbiota.
Detailed Description
The practice of physical exercise has numerous health benefits, preventing the appearance and development of cardiovascular diseases and various types of cancer. Exercise causes changes in the vascular, muscular and pulmonary systems, etc. One of the benefits that can result from exercise modification of the intestinal microbiota and its metabolic profile. In order to identify the potential changes that exercise has on the intestinal microbiota and its metabolic profile, the purpose of this study is to identify changes in the plasma and fecal metabolome and in fecal microbiota associated with a bout of exercise
Investigators
Mar Larrosa
Tenure Professor
Universidad Europea de Madrid
Eligibility Criteria
Inclusion Criteria
- •18-45 years of age
- •high physical condition (VO2 ≥ 55 ml/kg/min)
- •BMI 18-25 kg/m2
Exclusion Criteria
- •antibiotics intake during 3 months prior to the study,
- •nutritional complements
- •ergogenic complements
- •prebiotics
- •probiotics
- •vegetarian or vegan diet
- •chronic medication
- •gastrointestinal surgery
- •Any diagnosed disease
Outcomes
Primary Outcomes
Plasma metabolome profile
Time Frame: Changes from baseline to 30 min after the exercise intervention
Abundance of blood metabolites, metabolic networks, and metabolic pathways activity
Fecal microbiota
Time Frame: Changes from baseline to 30 min after the exercise intervention
Abundance of gut microbial taxa, communities, and metabolic pathways activity