Molecular Characterization of Primary Mucosal Melanoma

Completed

• Conditions: Mucosal Melanoma
• Interventions: Genetic: Somatic Genetic

• Registration Number: NCT03319693
• Lead Sponsor: CHU de Reims

Brief Summary

Primary mucosal melanomas (MPM) are rarer than cutaneous melanomas, but also more severe. They are usually refractory to conventional approaches, regularly excluded from major therapeutic programs and not sensitive to new targeted therapies orphans. " The identification of therapeutic targets and accessibility to existing, developing or future targeted therapies improves the survival of patients with MPM.

The principal goal is to describe, using a large panel of genes, the prevalence of major mutations in a cohort of MPMs based on the population of a French region.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-28
• Study First Submitted: 2017-10-20
• Study First Submitted QC: 2017-10-23
• Study First Posted: 2017-10-24
• Primary Completion: 2019-04-28
• Study Completion: 2021-04-28
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mucosal melanoma	Somatic Genetic	Incident Mucosal melanoma in the Champagne-Ardenne region 2004-2014

Primary Outcome Measures

Name	Time	Method
The frequency of main mutations identified using the NGS panel	Day 0	NGS panel

Trial Locations

Locations (1)

Chu Reims; 🇫🇷 Reims, France