Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma

Recruiting

• Conditions: Gene Abnormality; Mesothelioma, Malignant; Pleural Mesothelioma
• Interventions: Genetic: PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA

• Registration Number: NCT04823741
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Malignant pleural mesothelioma (MPM) is a rare pleural cancer, which could be primary or secondary to an asbestos exposure. To enhance our knowledge of this rare disease, an exploration of genetic and tumor mechanism is mandatory. One of the principal difficulty is to harvest sufficient tumour pieces to perform multi-omics analysis. The goal of the SCITH-MESO study is to harvest larges pieces of tumour during a routine surgical procedure of MPM diagnosis by mean of pleural biopsies during VATS surgery. Operating samples will increase a tissue bank collection (CRB).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-26
• Study First Submitted QC: 2021-03-26
• Study First Posted: 2021-04-01
• Study Start: 2022-02-11
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-30
• Last Update Posted: 2024-02-01
• Primary Completion: 2026-02-11
• Study Completion: 2026-02-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age >18
• suspected MPM requiring VATS biopsy after multidisciplinary oncologic board validation
• patient able to understand study objectives and able to give an informed consent
• patient affiliated to an healthcare society.

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Exclusion Criteria

• pregnancy
• mental disease, psychiatric disorder
• patient under protection regimen

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA	PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA	All patient with suspected malignant pleural mesothelioma requiring surgical biopsy after validation in oncologic multidisciplinary board will be included. During a standardized routine procedure of pleural biopsy by mean of general anesthesia and video thoracoscopic approach, 3 - 5 biopsies are realized. During this procedure, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).

Primary Outcome Measures

Name	Time	Method
For patients with MPM, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).	day 1 (day of chirurgie)	For patients with MPM, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).

Trial Locations

Locations (1)

Département de chirurgie thoracique; 🇫🇷 Bron, France