Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Rate of oxytocin
研究概览
简要总结
Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that subjects treated with a GLP-1 agonist have a significant change in their oxytocin levels compared with subjects not treated with a GLP-1 agonist.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient over 18 years of age.
- •Patient able to read and understand the information/consent leaflet.
- •Patient with BMI > 35 with at least one comorbidity. Or BMI > 40
- •Indication for digestive surgery validated in a multidisciplinary consultation meeting and prior agreement accepted by the CPAM.
- •Membership of a social security scheme
- •Patient's signed informed consent
- •For subjects in the GLP-1 analogue group: GLP-1 analogue taken for at least 3 months.
- •For non-GLP-1 analogue group: never taken GLP-1 analogues.
排除标准
- •Pregnant or breast-feeding women.
- •Vulnerable patients (under guardianship)
- •Patients deprived of liberty
研究组 & 干预措施
whole blood in a GLP1
Oxytocyne assay in a GLP1 analogue or non-analogue patient population
干预措施: Blood GLP1 (Other)
whole blood in non analague patient population
Oxytocyne assay in a GLP1 analogue or non-analogue patient population
干预措施: Blood No treated GLP1 (Other)
结局指标
主要结局
Rate of oxytocin
时间窗: one time (before surgery)
show that subjects treated with a GLP-1 agonist have a significant change in oxytocin levels compared with subjects not treated with a GLP-1 agonist.
次要结局
- Fibrosis rate(At surgery)