The Comparison of Multimodal Analgesic Protocols for Laparoscopic Cholecystectomy: Pharmacologic Interventions and Combination of Pharmacologic and Operative Interventions
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Area under curve of postoperative pain for 24 hour
研究概览
简要总结
It is important to decrease the postoperative pain in patients undergoing laparoscopic cholecystectomy. We will compare the pharmacologic analgesia with the parmacologic and surgical analgesia in patients undergoing laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective laparoscopic cholecystectomy
排除标准
- •Recent gastric ulcer disease
- •Hepatic or renal insufficiency
- •Opioid dependency
- •Coagulopathy
- •Pre-existing neurologic or anatomic deficits in the lower extremities
- •Severe psychiatric illness
研究组 & 干预措施
Pharmacological group
Pharmacological analgesia will be performed
干预措施: Celebrex, acetaminophen, and dexamethasone (Drug)
Pharmacologican and surgical group
Pharmacological and surgical analgesia will be performed.
干预措施: Celebrex, acetaminophen, and dexamethasone (Drug)
Pharmacologican and surgical group
Pharmacological and surgical analgesia will be performed.
干预措施: Saline irrigation, aspiration of pneumoperitoneum, and low pressure penumoperitoneum (Procedure)
结局指标
主要结局
Area under curve of postoperative pain for 24 hour
时间窗: At postoperative 24 hour
Area under curve will be measured using Postoperative pain score at postoperative 24 hour using visual anlogue scale (0: no pain, 10: most imaginable pain).
次要结局
- Analgesic requirements,(At postoperative 24 hour)
- Postoperative pain score,(At postoperative 0, 2, 6, and 24 hour)
- Sleep quality(At postoperative 24 hour)
研究者
Do-Hyeong Kim
Associate professor
Gangnam Severance Hospital