The Comparison of Multimodal Analgesic Protocols for Laparoscopic Cholecystectomy: Pharmacologic Interventions and Combination of Pharmacologic and Operative Interventions
Overview
- Phase
- Phase 3
- Intervention
- Celebrex, acetaminophen, and dexamethasone
- Conditions
- Laparoscopic Cholecystectomy
- Sponsor
- Gangnam Severance Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Area under curve of postoperative pain for 24 hour
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
It is important to decrease the postoperative pain in patients undergoing laparoscopic cholecystectomy. We will compare the pharmacologic analgesia with the parmacologic and surgical analgesia in patients undergoing laparoscopic cholecystectomy.
Investigators
Do-Hyeong Kim
Associate professor
Gangnam Severance Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective laparoscopic cholecystectomy
Exclusion Criteria
- •Recent gastric ulcer disease
- •Hepatic or renal insufficiency
- •Opioid dependency
- •Coagulopathy
- •Pre-existing neurologic or anatomic deficits in the lower extremities
- •Severe psychiatric illness
Arms & Interventions
Pharmacological group
Pharmacological analgesia will be performed
Intervention: Celebrex, acetaminophen, and dexamethasone
Pharmacologican and surgical group
Pharmacological and surgical analgesia will be performed.
Intervention: Celebrex, acetaminophen, and dexamethasone
Pharmacologican and surgical group
Pharmacological and surgical analgesia will be performed.
Intervention: Saline irrigation, aspiration of pneumoperitoneum, and low pressure penumoperitoneum
Outcomes
Primary Outcomes
Area under curve of postoperative pain for 24 hour
Time Frame: At postoperative 24 hour
Area under curve will be measured using Postoperative pain score at postoperative 24 hour using visual anlogue scale (0: no pain, 10: most imaginable pain).
Secondary Outcomes
- Analgesic requirements,(At postoperative 24 hour)
- Postoperative pain score,(At postoperative 0, 2, 6, and 24 hour)
- Sleep quality(At postoperative 24 hour)