Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals

Recruiting

• Conditions: Venous Sinus Thrombosis, Cranial

• Registration Number: NCT05413837
• Lead Sponsor: Capital Medical University

Brief Summary

The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.

Detailed Description

The classification of venous sinus and its variation based on the autopsy of patients can not fully reflect the real anatomy and variation of venous sinus in human, and the targeted research on healthy people is still unknown. The main purpose of this research is to use multimodal magnetic resonance technology to study the variation of venous sinus in Chinese healthy population, to preliminarily improve the anatomical classification of venous sinus in Chinese , to verify the the correlation between venous sinus variation and various non-genetic factors at the same time, as well as establishing reliable quantitative evaluation indicators.

Study Timeline

• Study First Submitted: 2022-06-06
• Study First Submitted QC: 2022-06-09
• Study First Posted: 2022-06-10
• Study Start: 2022-07-06
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-13
• Last Update Posted: 2023-04-18
• Primary Completion: 2023-08-31
• Study Completion: 2023-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Age 18 - 35 years old.
2. Confirmed no intracranial diseases, congenital abnormalities such as intracranial hematoma, tumor, vascular malformation, hydrocephalus, etc.
3. Voluntarily signed informed consent.

Exclusion Criteria

1. Any clinical history, including hypertension, diabetes, coronary heart disease, hematologic and rheumatic immune system diseases,cervical spondylosis, anxiety, depression, insomnia, etc.
2. Internal jugular venous outflow disturbance : MRV from extracranial to aortic arch demonstrates variation or stenosis of the internal jugular vein, vertebral plexus, brachiocephalic vein, and superior vena cava.
3. Any history of craniocerebral trauma or surgery that affected the existence and running of veins.Unhealthy habits such as smoking, heavy drinking, etc.
4. Women who are pregnant or in preparation for pregnancy or lactation.
5. Other conditions that the researchers considered might affect the trial and inappropriate for inclusion.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The anotomy and variation of venous sinus in Chinese healthy individuals	On the day of examination	According to the connection types of superior sagittal sinus and transverse sinus at the the torcular Herophili assessed with contrast-enhanced MR venography and phase-contrast MR venography, describe the anatomical classification of venous sinus based on the anatomical descriptions of Osborn and describe the anatomical variations that are not included in the existing classification. Calculating the proportion of each type.

Secondary Outcome Measures

Name	Time	Method
Serum biomarkers in Chinese healthy individuals	On the day of examination	The level of biomarkers are detected using Elisa or omics analysis
The diameters of venous sinus and small veins in Chinese healthy individuals	On the day of examination	Measuring the diameters of venous sinus and small veins assessed with contrast-enhanced MR venography

Trial Locations

Locations (1)

Xuanwu hospital;Capital Medical University; 🇨🇳 Beijin, XI Cheng District, China