Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- The Borg Rating of Perceived Exertion (RPE) scale
研究概览
简要总结
Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.
详细描述
Menopause is defined as a point in time 12 months after a woman's last period. During the menopausal transition, changes in estrogen and progesterone levels affect not only vasomotor symptoms, sexual dysfunction, osteoporosis, and cardiovascular disease (CVD), but also uric acid level1. An association between menopausal status and hyperuricemia has been previously examined. A study using the Third National Health and Nutrition Examination Survey showed a positive and independent association of menopause with hyperuricemia and gout. It's believed that estrogen has a protective effect that is removed at menopause, thus accounting for the rise in gout in women who are postmenopausal2.
Hyperuricemia is a common biochemical abnormality resulting from excessive uric acid production or impaired clearance of uric acid. Although its pathophysiology is not fully understood, genetic, comorbid disease-related, and environmental (drug, diet, and toxic exposure-induced) factors are involved in hyperuricemia3.
Gout is a multifactorial disease caused by hyperuricemia and monosodium urate crystals deposition. Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours. The joint at the base of the big toe is affected in about half of cases4.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •100 patients with gout
- •Age between 45 -65 years
- •Cooperative patient.
- •A physician referred all patients with the diagnosis of gout
排除标准
- •history of kidney disease such as chronic kidney disease, Cancer patients. Smokers Patients with chronic heart disease.
结局指标
主要结局
The Borg Rating of Perceived Exertion (RPE) scale
时间窗: 2 week before and 2 week after
will be used to measure the level of exertional effort for both groups A \& B before and after treatment
Serum uric acid level before and after treatment for both groups (A and B): Table 2: Mean values for Serum uric acid level before and after treatment for both groups (A and B).
时间窗: 2 week before and 2 week after
a sample of blood was used to assess the level of uric acid in the blood for both groups A \& B before and after treatment
Visual analogue scale before and after treatment for both groups (A and B): Chicago, Illinois, USA). The P-value is the degree of significance. A P value less than or equal to 0.05 was considered to be significant.
时间窗: 2 week before and 2 week after
consists of a straight line with the endpoints defining extreme limits such as 'no pain at all' and 'pain as bad as it could be. The patient was asked to mark her pain level on the line between the two endpoints. The distance between 'no pain at all' and the mark then defines the subject's pain intensity .
Digital blood pressure monitor
时间窗: 2 week before and 2 week after
It measures blood pressure (systolic \& diastolic) quickly, is easy to use, reliable, and convenient to carry. The monitor has a display that shows systolic blood pressure and diastolic blood pressure. The machine comes with an arm cuff with an air tube and an air jack for connecting the cuff to the machine
次要结局
未报告次要终点