The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly

Not Applicable

• Conditions: PND
• Interventions: Device: nerve block combined with general anesthesia; Device: spinal anesthesia

• Registration Number: NCT04488952
• Lead Sponsor: Shenzhen Second People's Hospital

Brief Summary

Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-08
• Study First Submitted: 2020-07-22
• Study First Submitted QC: 2020-07-24
• Study First Posted: 2020-07-28
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-26
• Last Update Posted: 2022-04-28
• Primary Completion: 2023-12-31
• Study Completion: 2024-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

• aged 60-85years
• ASA I-III
• Received elective surgery of unilateral lower extremity orthopedics
• The anesthesia lasted more than 2 hours

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nerve block combined with general anesthesia group	nerve block combined with general anesthesia	Patients in this group receive nerve block combined with general anesthesia.
spinal anesthesia group	spinal anesthesia	Patients in this group receive spinal anesthesia.
nerve block combined with general anesthesia group	spinal anesthesia	Patients in this group receive nerve block combined with general anesthesia.
control group	spinal anesthesia	This group is used to obtain the learning effect.
spinal anesthesia group	nerve block combined with general anesthesia	Patients in this group receive spinal anesthesia.
control group	nerve block combined with general anesthesia	This group is used to obtain the learning effect.

Primary Outcome Measures

Name	Time	Method
Incidence of PND seven days after surgery	seven days after surgery

Secondary Outcome Measures

Name	Time	Method
ADL of temporal lobe	one day pre-operation, one week post-operation
ADL of occipital lobe	one day pre-operation, one week post-operation
Incidence of PND one month after surgery	one month after surgery
One year event-free survival	one year after surgery
Incidence of PND one year after surgery	one year after surgery
Hospital stay	one to two weeks after surgery
Number of patients entrance the ward of ICU after surgery	one week post-operation
Mortality rate	one year after surgery
Postoperative complications	one month post-operation
ADL of frontal lobe，temporal lobe and occipital lobe	one day pre-operation, one week post-operation
ADL of frontal lobe	one day pre-operation, one week post-operation
BOLD of the whole brain	one day pre-operation, one week post-operation

Trial Locations

Locations (1)

Shenzhen Second People's Hospital; 🇨🇳 Shenzhen, Guangdong, China