Study for Perioperative Neurocognitive Disorders After Deep Brain Stimulation Surgery for Parkinson's Disease
- Conditions
- Neurocognitive Disorders
- Registration Number
- NCT04696978
- Lead Sponsor
- wenbinlu
- Brief Summary
Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown. Metabolites could reveal chemical fingerprints left behind by cellular processes, which in turn provide a new aspect to understand the biological process behind. we aim to found the metabolomics can aid the development of diagnostic markers of PND screening, early detection, and further, provide a basis for disease prevention and treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Parkinson's patients undergoing elective deep brain stimulation
- Age ≥55 years
- ASA physical statusⅠ-Ⅲ
- Elementary school or above
Exclusion Criteria
- patients with ASA physical status>III
- patients with systemic immune diseases, hematological diseases (hematological tumors or leukemia), patients after transplantation, malignant tumors
- patients with metabolic diseases such as diabetes, ketoacidosis, hyperosmolar syndrome, long-term hypoglycemia,gout
- patients who refused to join the study and lost to follow-up
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the level of metabolomics in patients' blood sample 72 hours after operation
- Secondary Outcome Measures
Name Time Method CAM-ICU score 1 month after operation
Trial Locations
- Locations (1)
Changhai Hospital, Second Military Medical University
🇨🇳Shanghai, Shanghai, China