The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly: a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- PND
- Sponsor
- Shenzhen Second People's Hospital
- Enrollment
- 350
- Locations
- 1
- Primary Endpoint
- Incidence of PND seven days after surgery
- Last Updated
- 4 years ago
Overview
Brief Summary
Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.
Investigators
ZhiHeng Liu
Chair of Department of Anesthesiology
Shenzhen Second People's Hospital
Eligibility Criteria
Inclusion Criteria
- •aged 60-85years
- •ASA I-III
- •Received elective surgery of unilateral lower extremity orthopedics
- •The anesthesia lasted more than 2 hours
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Incidence of PND seven days after surgery
Time Frame: seven days after surgery
Secondary Outcomes
- ADL of temporal lobe(one day pre-operation, one week post-operation)
- ADL of occipital lobe(one day pre-operation, one week post-operation)
- Incidence of PND one month after surgery(one month after surgery)
- One year event-free survival(one year after surgery)
- Incidence of PND one year after surgery(one year after surgery)
- Hospital stay(one to two weeks after surgery)
- Number of patients entrance the ward of ICU after surgery(one week post-operation)
- Mortality rate(one year after surgery)
- Postoperative complications(one month post-operation)
- ADL of frontal lobe，temporal lobe and occipital lobe(one day pre-operation, one week post-operation)
- ADL of frontal lobe(one day pre-operation, one week post-operation)
- BOLD of the whole brain(one day pre-operation, one week post-operation)