NCT04696978Unknown不适用
Metabonomics Characteristics and Predictive Value for Perioperative Neurocognitive Disorders After Deep Brain Stimulation Surgery for Parkinson's Disease
wenbinlu1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2020年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- the level of metabolomics in patients' blood sample
研究概览
简要总结
Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown. Metabolites could reveal chemical fingerprints left behind by cellular processes, which in turn provide a new aspect to understand the biological process behind. we aim to found the metabolomics can aid the development of diagnostic markers of PND screening, early detection, and further, provide a basis for disease prevention and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Parkinson's patients undergoing elective deep brain stimulation
- •Age ≥55 years
- •ASA physical statusⅠ-Ⅲ
- •Elementary school or above
排除标准
- •patients with ASA physical status>III
- •patients with systemic immune diseases, hematological diseases (hematological tumors or leukemia), patients after transplantation, malignant tumors
- •patients with metabolic diseases such as diabetes, ketoacidosis, hyperosmolar syndrome, long-term hypoglycemia,gout
- •patients who refused to join the study and lost to follow-up
结局指标
主要结局
the level of metabolomics in patients' blood sample
时间窗: 72 hours after operation
次要结局
- CAM-ICU score(1 month after operation)
研究者
wenbinlu
Principal Investigator
Changhai Hospital
研究点 (1)
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