ACIT-2: An observational study investigating the systemic inflammatory, coagulation and genomic response in humans to severe injury and bleeding after major trauma

Not Applicable

• Conditions: Molecular and cellular responses to traumatic injury in severely injured and bleeding adults and children; Injury, Occupational Diseases, Poisoning

• Registration Number: ISRCTN12962642
• Lead Sponsor: Queen Mary University of London

Brief Summary

2015 Abstract results in http://doi.org/10.1186/1757-7241-23-s2-a8 (added 31/03/2021) 2020 Interim results article in http://doi.org/10.1097/SLA.0000000000003771 (added 31/03/2021) 2014 Interim results article in http://doi.org/10.1097/TA.0000000000000146 (added 31/03/2021) 2013 Interim results article in http://doi.org/10.1097/SHK.0b013e31828ded41 (added 31/03/2021) 2019 Interim results article in http://doi.org/10.1097/SLA.0000000000002733 (added 31/03/2021) 2013 Interim results article in http://doi.org/10.1097/ta.0b013e3182788b0f (added 31/03/2021) 2017 Interim results article in http://doi.org/10.1097/ALN.0000000000001428 (added 31/03/2021) 2015 Interim results article in http://doi.org/10.1007/s00134-014-3584-1 (added 31/03/2021) 2012 Interim results article in https://doi.org/10.1111/jth.12078 (added 31/03/2021) 2021 Interim results article in http://doi.org/10.1097/sla.0000000000003657 (added 31/03/2021) Interim results article in https://doi.org/10.1002/bjs.8728 (added 31/03/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34724559/ Secondary analysis (added 02/11/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-03-31
• Last Update Posted: 8 April 2024
• Study Completion: 2037-01-07

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

All trauma patients regardless of age can be screened for inclusion in hospital (adults only in prehospital care)

Exclusion Criteria

1. Transfers from other hospitals
2. Burns > 5% total body surface area
3. More than 120 mins have lapsed since time of injury
4. Deemed inappropriate for recruitment by an independent clinician

Study & Design

• Study Type: Observational
• Study Design: Not specified