NCT01254110已完成不适用
Physiological Study on Glutamine and Leucine Effects on Intestinal Protein Metabolism
University Hospital, Rouen1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2009年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- assessment of intestinal protein synthesis stimulation by Leucine or glutamine in duodenal biopsy
研究概览
简要总结
Gut protein metabolism that could be influenced by protein supply is involved in the regulation of several physiological functions such as gut barrier function and represents a major contribution in the whole-body protein turnover. Intracellular pathways implicated in the transduction of amino acids effects remained unknown in the human gut. Thus, the aim of the present project is to evaluate and to understand the effects of amino acids (glutamine, leucine) on gut protein metabolism (synthesis and degradation) in young healthy humans.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •volunteers with seronegativity for HIV1 and HIV2 and HCV and HVB
- •good nutritional state with physical indication mass included between 18,5 and 25kg/m2
- •non-smoking volunteers
- •volunteers without digestive, allergic or haemorrhagic history
- •volunteers without progressive disease
- •digestive endoscopy tolerance
- •age >=18 and <= 50years
- •consent obtained from volunteers
排除标准
- •smoking volunteers
- •volunteers with digestive, or allergic history
- •volunteers with haemorrhagic sign
- •pregnancy
- •progressive digestive disease
- •significant progressive disease
- •volunteers with therapeutic treatment (aspirin)
- •digestive endoscopy intolerance
- •volunteers with neurological disorder or with delicate psychological state
结局指标
主要结局
assessment of intestinal protein synthesis stimulation by Leucine or glutamine in duodenal biopsy
时间窗: 18 months
次要结局
- Assessment of involved signaling pathways(18 months)
- Assessment of intestinal proteolysis(18 months)
- Assessment of protein synthesis rate in intestinal mitochondria(18 months)
研究者
研究点 (1)
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