Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Impact on protein synthesis rate and proteolytic activities in intestine.
研究概览
简要总结
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated.
Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers, male and female, aged between 18 and 50 years, negatives for HIV1, 2 and for HVC and HVB
- •BMI between 20 and 24 kg/m²,
- •giving their written informed consent
- •no-smokers
- •no allergic and digestive antecedents
排除标准
- •Allergic and digestive antecedents,
- •pregnancy
结局指标
主要结局
Impact on protein synthesis rate and proteolytic activities in intestine.
时间窗: at the end of infusion (hour 5)
次要结局
- Comparison of protein expression pattern and glutathione synthesis.(at the end of infusion (hour 5))