Identifying Genetic Causes of IC/BPS

Recruiting

• Conditions: Chronic Pelvic Pain Syndrome; Interstitial Cystitis; Bladder Pain Syndrome

• Registration Number: NCT00389142
• Lead Sponsor: Boston Children's Hospital

Brief Summary

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS), or chronic pelvic pain syndrome(CPPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another.

In this study, we are collecting genetic material and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS/CPPS. We are enrolling families and individuals with IC/BPS/CPPS and their family members (both family members with and without IC like symptoms).

Detailed Description

We are trying to identify a genetic cause of interstitial cystitis (IC)/bladder pain syndrome (BPS)/chronic pelvic pain syndrome (CPPS). We will enroll individuals and families with IC/BPS/CPPS to fully describe the symptoms of IC/PBS/CPPS in adults and children. We will attempt to determine if the symptoms of IC/PBS/CPPS match or indicate changes in specific genes or a pathway of connected genes. We will use several genetic technologies including but not limited to; linkage analysis, whole exome sequencing and candidate gene studies to try to identify the cause of IC/BPS/CPPS. We hope this will lead us to better more effective treatments for affected individuals. We are looking for families with IC/BPS/CPPS symptoms to give a DNA sample (from blood/saliva), urine samples, bladder tissue from clinical biopsy and answer several questionnaires. Travel to Boston NOT necessary.

Study Timeline

• Study Start: 2006-01-15
• Study First Submitted: 2006-10-17
• Study First Submitted QC: 2006-10-17
• Study First Posted: 2006-10-18
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-30
• Last Update Posted: 2024-07-03
• Primary Completion: 2025-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

• Diagnosis of IC/BPS/CPPS
• Males and females of any age
• Urinary frequency - more than 1X/hour, and/or
• Dysuria, and/or
• Pelvic, suprapubic, or abdominal pain - for 3 months or longer
• Nocturia
• Normal urinary stream (by history)
• No evidence of active bacterial UTI (no pyuria & negative urinary culture for last 3 months)
• First degree relative of someone with above symptoms

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Exclusion Criteria

• Major structural/anatomical urinary tract abnormalities by ultrasound
• Underlying inborn conditions affecting the urinary tract
• Surgery/chemotherapy affected pelvic area
• GI or GU cancers
• Severe Constipation in children only

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
observational study	through study completion, average of 10 years	Outcome is candidate or causative genes for causing IC/BPS.

Trial Locations

Locations (1)

Boston Children's Hospital (BCH); 🇺🇸 Boston, Massachusetts, United States