Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft
- Conditions
- Atrial Fibrillation
- Interventions
- Registration Number
- NCT00654290
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG
- Detailed Description
In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).
All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 240
- Patient who are going to have elective CABG
- Signing informed consent
- EF<35%
- Bradycardia<60 per min
- Hypotension< 100 mmhg
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description P Propranolol Propranolol from 7 days pre-operation to 5 days post CABG A Amiodarone Amiodarone treated 7 days pre-operation to 5 days post CABG AP Amiodarone + Propranolol Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG
- Primary Outcome Measures
Name Time Method incidence of atrial fibrillation post CABG 7 days post CABG
- Secondary Outcome Measures
Name Time Method bradycardia, mortality, hypotension, morbidity 7 days post CABG
Trial Locations
- Locations (1)
Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital
🇮🇷Shiraz, Fars, Iran, Islamic Republic of