Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- incidence of atrial fibrillation post CABG
研究概览
简要总结
Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG
详细描述
In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).
All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient who are going to have elective CABG
- •Signing informed consent
排除标准
- •Bradycardia<60 per min
- •Hypotension< 100 mmhg
研究组 & 干预措施
P
Propranolol from 7 days pre-operation to 5 days post CABG
干预措施: Propranolol (Drug)
A
Amiodarone treated 7 days pre-operation to 5 days post CABG
干预措施: Amiodarone (Drug)
AP
Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG
干预措施: Amiodarone + Propranolol (Drug)
结局指标
主要结局
incidence of atrial fibrillation post CABG
时间窗: 7 days post CABG
次要结局
- bradycardia, mortality, hypotension, morbidity(7 days post CABG)