Dissociating prediction and attention in the brain: a combined TMS-EEG study

Conditions: n.v.t.
niet van toepassing

Registration Number: NL-OMON32937

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Right-handed individuals, with normal or corrected-to-normal vision and no history of neurological or psychological disorders are included.

Exclusion Criteria

- Pacemaker
- Metal parts in head or mouth
- History of brain surgery
- History of epilepsy or first-grade family member with epilepsy
- Psychological or neurological disorder
- Pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The effect of TMS on the three stimulation sites will be assessed using<br /><br>concurrently measured EEG. We will test whether stimulation to LOC, OFA, and<br /><br>vertex differentially affect the TMS-induced evoked potential, as a function of<br /><br>predictability and attention. We hypothesize that predictability will lead to a<br /><br>strengthening of backward connectivity (Friston 2005), in a stimulus-specific<br /><br>manner and irrespective of the attentional set. Attention is hypothesized to<br /><br>have an additive effect on backward connection strength that does not interact<br /><br>with predictability (Morishima, Akaishi et al. 2009). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We will also measure behavioural performance (reaction times and error rates)<br /><br>during the experiment, as the subjects task is to respond as quickly as<br /><br>possible to one of the two shapes. We will probe whether, at the low<br /><br>intensities of TMS applied, the RT gain for anticipated stimuli will be<br /><br>diminished or abolished by TMS intervention. </p><br>