Effects of Physical Exercise in movements, manual hability and brain plasticity in individuals with Parkinson's disease
- Conditions
- Parkinson disease
- Registration Number
- RBR-7zjgnrx
- Lead Sponsor
- aboratório de Neurociências - Universidade Federal de São Carlos
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
The inclusion criteria will be age between 40 to 80 years; both genders; diagnosis of Parkinson's disease as confirmed by neurologist; stage 1-3 on the Hoeh and Yahr scale; who were not exercising at moderate intensity greater than 3 times per week within 3 months; complaints about motor impairments related to hand function (self-report); taking stable medications for Parkinson's disease for at least 30 days
The exclusion criteria will be features suggestive of other causes of parkinsonism/ Parkinson’s-plus syndromes, unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease), psychiatric diseases diagnosed by a psychiatrist; dementia (Mini-Mental State Examination score less than 24), presence of another neurological disorder and hearing or visual impairment
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be the Unified Parkinson’s Disease Rating Scale (UPDRS): motor<br>function part III that is a comprehensive assessment designed to assess Parkinson's disease across the disease course and provide clinical endpoints in therapy trials. We hypothesized that there will be clinically relevant improvement after interventions compared to control.
- Secondary Outcome Measures
Name Time Method The secondary objective is evaluate the neuroplasticity effects of those interventions indexed<br>by resting and task-related quantitative electroencephalography (motor execution, motor observation, and motor imagery). Our hypothesis is that there will be higher spectral power at high-frequencies bands (alpha and beta), and higher beta-ERS in the sensorimotor areas after exercise protocols compared with control groups; we hypothesized that electroencephalography changes will correlate with the upper limb function improvement indexed by UPDRS III.;The secondary outcome manual dexterity will be measured by the Nine-Hole Peg Test (9-HPT). We hypothesized that there will be clinically relevant improvement after interventions compared to control.