PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin

Recruiting

• Conditions: Acute Kidney Injury

• Registration Number: NCT06714214
• Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Brief Summary

The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-09
• Study Start: 2024-10-01
• Study First Submitted: 2024-11-28
• Study First Submitted QC: 2024-11-28
• Study First Posted: 2024-12-03
• Last Update Submitted: 2024-12-05
• Last Update Posted: 2024-12-10
• Primary Completion: 2026-08
• Study Completion: 2026-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

• age ≥ 18 years;
• diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
• need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
• Obtaining informed consent

Exclusion Criteria

• CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
• need for RRT (any type and modality) in the 14 days prior to enrolment;
• diagnosis of AKD/CKD/ESRF on admission;
• Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
• Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
• pregnant women;
• presence of known thyreopathy
• Continuous use of corticosteroids
• patient with known neoplastic disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU	From enrlollment to the weaning from CRRT and 14 days after	To verify whether the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU It is measured as (cistatin at weaning minus cistatin basal) divided by cistatine basal, in percentage

Trial Locations

Locations (2)

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Anestesia e Terapia Intensiva nelle emergenze locali, regionali e nazionale e nella chirurgia addominale maggiore; 🇮🇹 Bologna, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna -Anestesiologia e terapia intensiva polivalente; 🇮🇹 Bologna, Italy