Partnership to Enhance Antimicrobial Use in Resource-Limited Settings (PEARL): An Assessment of Need and Feasibility of Antimicrobial Stewardship Programs
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Resistance Bacterial
- Sponsor
- Duke University
- Enrollment
- 3115
- Locations
- 1
- Primary Endpoint
- Appropriate antimicrobial use, for example for urinary syndromes
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Antimicrobial resistance is one of the greatest threats to human health, and is driven by inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs) improve the use of antimicrobials in hospitals. The purpose of this study is to identify the need for and barriers to implementation of ASPs in three hospitals in Sri Lanka, Kenya, and Tanzania.
Detailed Description
Antimicrobial resistance is one of the greatest threats to human health, and is driven by the inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs) improve the use of antimicrobials. The purpose of this study is to identify the need for and barriers to implementation of ASPs in three hospitals in Sri Lanka, Kenya, and Tanzania. The impact of creating a basic ASP will be assessed at each hospital.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All patients admitted to the medical wards -
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Appropriate antimicrobial use, for example for urinary syndromes
Time Frame: 6 months
A composite outcome will be created for 'inappropriate' antibiotic use. This outcome will consist of 1) Unnecessary treatment for asymptomatic bacteriuria, 2) Inappropriate duration of therapy for urinary tract infection (UTI)/ cystitis/ pyelonephritis (binary outcome- yes/no), and 3) Unnecessary double coverage for UTI/ cystitis/ pyelonephritis (binary outcome- yes/no)