Investigating the effect of neoadjuvant chemotherapy on locally advanced rectal cancer
Phase 3
- Conditions
- ocally advanced Rectal cancers.
- Registration Number
- IRCT20210308050628N1
- Lead Sponsor
- Hamedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
age between 18-75
Rectal cancer(Adenocarcinoma) confirmed by pathology
locally advanced tumors
No distant metastasis
Proper Performance status(PS: 0-1)
proper blood condition
proper renal function
proper liver function
Exclusion Criteria
Recurrent rectal cancer
previous pelvic radiotherapy
history of other malignancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pathological complete response, down-staging of tumor invasion and lymph nodes involvement, 3-years disease free survival. Timepoint: Before treatment, During treatment, after treatment and 3 years follow up. Method of measurement: Pathology, Clinic and Paraclinic.
- Secondary Outcome Measures
Name Time Method