Emotional Processing in Multiple Sclerosis / Clinically Isolated Syndrome: A Neuropsychological fMRI-study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis (MS)
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Emotional memory performance
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of this prospective non-interventional neuropsychological one visit study involving functional MRI (fMRI) is to ascertain emotional processing in patients with Multiple Sclerosis (MS) or Clinically Isolated Syndrome (CIS) compared to healthy control subjects.
In different experiments, the modulation of cognitive and motor responses by visual emotional information and the ability to discriminate visual emotional stimuli will be tested using experimental behavioral paradigms. Furthermore, functional connectivity and - using fMRI - activations of brain regions known to be involved with emotional processing will be evaluated.
Investigators
PD Dr. Thomas Hälbig
MD
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years and ≤ 85 years
- •Right handed
- •For patients: Diagnosis of CIS or diagnosis of MS since ≤5 years
Exclusion Criteria
- •Cognitive deficits as determined by a MMSE Score \< 25/30
- •Depression as determined by a HADS-D Score \> 7
- •Anxiety as determined by a HADS-A Score \> 7
- •Physical disabilities interfering with the study procedures or impacting outcome measures
- •Clinically significant diseases within 7 days prior to the study evaluations
- •Contraindications against cranial MRI without contrast
Outcomes
Primary Outcomes
Emotional memory performance
Time Frame: 1 day
%-correct recognized emotional and neutral stimuli
Emotional modulation of motor response time
Time Frame: 1 day
Δ (\[Response time following neutral stimuli\] - \[Response time following emotional stimuli\])
Emotional experience
Time Frame: 1 day
Subjective valence and arousal ratings of emotional and neutral stimuli
Secondary Outcomes
- Satisfaction With Life Scale (SWLS)(1 day)
- Short Form Health Survey (SF-36)(1 day)
- Expanded Disability Status Scale (EDSS)(1 day)
- Multiple Sclerosis Functional Composite (MSFC)(1 day)
- Symbol Digit Modalities Test (SDMT)(1 day)
- Serial Reaction Time (SRT) Task(1 day)
- BOLD-fMRI brain responses during emotional processing(1 day)
- Paced Auditory Serial Addition Test (PASAT)(1 day)
- Beck depression inventory BDI-2(1 day)
- Positive and Negative Affect Schedule (PANAS)(1 day)