Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 144
- 试验地点
- 1
- 主要终点
- Pain
研究概览
简要总结
Patients frequently experience pain from moderate to severe during gynecologic procedures. This study is a prospective, randomized, placebo-controlled trial and aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure.
详细描述
A total of 144 mutiparous subjects randomly allocated one of six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group consisted of 26 participants receiving oral 25 mg dexketoprofen trometamol. The third group consisted of 23 participants receiving 2 puff lidocaine sprays on cervical mucosa. The forth group consisted of 25 participants receiving 100 mg pethidine. The fifth group consisted of 23 participants receiving 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •multiparous participants
- •abnormal uterine bleeding
- •postmenopausal bleeding
- •myoma uteri causing menometrorrhagia
- •cervical polyp
- •tamoxifen treatment for breast cancer
- •adnexial mass
排除标准
- •abortions
- •pregnancy
- •primiparity
- •diabetes mellitus
- •tendency to bleed such as thrombocytopenia
- •factor deficiency
- •functional disorders of platelets
研究组 & 干预措施
Pain reliever
1000 mg paracetamol (Parol 1 g Atabay ilaç Turkey)
干预措施: comparison of pain relievers during curattage (Drug)
pethidine
Aldolan 100 mg Liba Laboratuarı İstanbul Turkey
干预措施: comparison of pain relievers during curattage (Drug)
Dexketoprofen trometamol
25 mg oral Dexofen Atabay ilaç Turkey
干预措施: comparison of pain relievers (Drug)
Lidocaine spray
2 puff on cervical mucosa (Xylocain Pump 100 Mg 50 Ml Sprey Astra Zeneca)
干预措施: comparison of pain relievers during curattage (Drug)
diclofenac sodium
Dicloron amp 75 mg Deva İlaç Levent İstanbul/Turkey
干预措施: comparison of pain relievers during curattage (Drug)
结局指标
主要结局
Pain
时间窗: 1 year
次要结局
未报告次要终点
研究者
Gökhan Açmaz
MD
Kayseri Education and Research Hospital