NCT01308073已完成不适用
Long-time Stability of Middle Molecule Clearance During CI-Ca CVVHD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Clearance of Cystatin C
研究概览
简要总结
The investigators aim to show, whether all middle molecules are included in the clearance and whether this clearance is stable until 72 hours.
详细描述
A better middle molecule clearance has been shown until 24 hours of duration. The investigators will extend our observations until 72 hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •informed consent
- •age>18 years
- •acute renal insufficiency with indication for continuous hemodialysis, according to RILFE classification F: serum creatinine increase > 3-fold or serum creatinine > 4mg/dl with acute increase of >0,5mg/dl Urine Output <0,3mg/kg/h for 24 h or anuria for 12 h
- •body weight:60-80kg
- •anticoagulation with citrate possible and indicated
- •Dose for hemodialysis of 2l/h
排除标准
- •participation in another clinical trial within on month prior to this study
- •pregnancy or brest feeding
- •septic shock
- •interference with cystatin-C
- •haemolysis <1g/dl
- •Bilirubin<9mg/dl
- •Triglyceride >700mg/dl
- •rheumatoid factor > 300kIU/l
结局指标
主要结局
Clearance of Cystatin C
时间窗: up to 72 h
Clearance of creatinine
时间窗: up to 72 h
Clearance of Urea
时间窗: up to 72 h
Clearance of albumin
时间窗: up to 72 h
Clearance of Beta2-Microglobulin
时间窗: up to 72 h
Free light chains kappa of Immunoglobulins
时间窗: up to 72 h
Clearance of Osteocalcin
时间窗: up to 72 h
次要结局
- Mean arterial pressure(up to 72 h)
- Heart rate(up to 72 h)
- Vasopressor requirement(up to 72 h)
研究者
Klinik für Anästhesiologie
Leiter Interdisziplinäre Operative Intensivstation ZOM-I
Heinrich-Heine University, Duesseldorf
研究点 (1)
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