Treatment of Atrophic Acne Scars With Platelet-Rich Plasma and Skin Needling

Not Applicable

Completed

• Conditions: Atrophic Acne Scars
• Interventions: Procedure: Platelet-Rich Plasma; Procedure: Micro-needling

• Registration Number: NCT02798016
• Lead Sponsor: Damascus University

Brief Summary

Investigators will collect blood specimens from the participating patients and then blood samples will be centrifuged in order to collect platelet-rich plasma which is going to be injected in the atrophic acne scars. A split-face design is going to used in this randomized controlled trial. In the control side of the face, micro-needling to the skin will occur using a specific tool (Dermapen).

Detailed Description

Atrophic acne scar is a common problem with a challenging treatment. Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition.

Skin needling is a technique that uses a sterile micro needles to puncture the skin and release growth factors. The combination of skin needling and PRP could enhance the efficacy of both modalities.

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2016-05-13
• Study First Submitted QC: 2016-06-08
• Study First Posted: 2016-06-14
• Primary Completion: 2017-06-23
• Study Completion: 2017-10-20
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-31
• Last Update Posted: 2018-01-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Atrophic acne scars on both sides of the face

Exclusion Criteria

• patients with active acne, herpes labialis, or bacterial infection; warts on the face, actinic keratosis, or skin cancer
• systemic retinoids intake in the previous 6 months,
• diabetes, pregnancy, history of keloidal scarring; or patients with severe systemic illness or malignancy
• patients on anticoagulant therapy or aspirin or have a coagulation issue,
• patients with hemoglobin less than 10g\dl or platelet less than 105 micron\l
• any previous procedures for acne scar within the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet-Rich Plasma alone	Platelet-Rich Plasma	The scars will be injected with Platelet-Rich Plasma alone.
Platelet-Rich Plasma with micro-needling	Micro-needling	The scars will be dealt with using micro-needling as well as injecting Platelet-Rich Plasma
Platelet-Rich Plasma with micro-needling	Platelet-Rich Plasma	The scars will be dealt with using micro-needling as well as injecting Platelet-Rich Plasma

Primary Outcome Measures

Name	Time	Method
Change in Scar Appearance	Scar Appearance will be assessed at: T1; one day (wihtin 24 hours) before the application of the intervention(s); and T2: after three months of applying the intervention(s).

Secondary Outcome Measures

Name	Time	Method
Patients' Satisfaction	This is going to be assessed six months following the application of the intervention and the active comparator	The assessment will be based on a questionnaire

Trial Locations

Locations (1)

Department of Dermatology and Venereology; 🇸🇾 Damascus, Syrian Arab Republic