Treatment of Atrophic Acne Scars With Platelet-Rich Plasma Alone or in Combination With Skin Needling: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Change in Scar Appearance
研究概览
简要总结
Investigators will collect blood specimens from the participating patients and then blood samples will be centrifuged in order to collect platelet-rich plasma which is going to be injected in the atrophic acne scars. A split-face design is going to used in this randomized controlled trial. In the control side of the face, micro-needling to the skin will occur using a specific tool (Dermapen).
详细描述
Atrophic acne scar is a common problem with a challenging treatment. Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition.
Skin needling is a technique that uses a sterile micro needles to puncture the skin and release growth factors. The combination of skin needling and PRP could enhance the efficacy of both modalities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Atrophic acne scars on both sides of the face
排除标准
- •patients with active acne, herpes labialis, or bacterial infection; warts on the face, actinic keratosis, or skin cancer
- •systemic retinoids intake in the previous 6 months,
- •diabetes, pregnancy, history of keloidal scarring; or patients with severe systemic illness or malignancy
- •patients on anticoagulant therapy or aspirin or have a coagulation issue,
- •patients with hemoglobin less than 10g\dl or platelet less than 105 micron\l
- •any previous procedures for acne scar within the last 6 months
研究组 & 干预措施
Platelet-Rich Plasma with micro-needling
The scars will be dealt with using micro-needling as well as injecting Platelet-Rich Plasma
干预措施: Platelet-Rich Plasma (Procedure)
Platelet-Rich Plasma alone
The scars will be injected with Platelet-Rich Plasma alone.
干预措施: Platelet-Rich Plasma (Procedure)
Platelet-Rich Plasma with micro-needling
The scars will be dealt with using micro-needling as well as injecting Platelet-Rich Plasma
干预措施: Micro-needling (Procedure)
结局指标
主要结局
Change in Scar Appearance
时间窗: Scar Appearance will be assessed at: T1; one day (wihtin 24 hours) before the application of the intervention(s); and T2: after three months of applying the intervention(s).
次要结局
- Patients' Satisfaction(This is going to be assessed six months following the application of the intervention and the active comparator)