Preoperative Two Hours Carbohydrate Load On Pediatric Patient Undergoing Elective Surgery

Not Applicable

Completed

• Conditions: Preoperative; Carbohydrate; Pediatric; Elective Surgery
• Interventions: Other: Apple juice; Drug: Anhydrous glucose; Other: Water

• Registration Number: NCT06833671
• Lead Sponsor: Tanta University

Brief Summary

This work evaluated the systemic effect of different preoperative carbohydrate (CHO) loads in pediatrics undergoing elective surgery.

Detailed Description

Children undergoing surgery experience stress due to disruptions in their daily routine and exposure to various perioperative circumstances that induce anxiety and pain.

The management of perioperative nutrition in pediatric patients is a crucial aspect of patient care.

The concept of preoperative carbohydrate (CHO) loading has gained attention as a potential strategy to mitigate these drawbacks. The administration of a CHO-rich drink two hours preoperative has been proposed to maintain euglycemia, decline IR, and enhance postoperative recovery

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2024-10-21
• Study Completion: 2024-10-21
• Status Verified: 2025-02
• Study First Submitted: 2025-02-13
• Study First Submitted QC: 2025-02-13
• Last Update Submitted: 2025-02-13
• Study First Posted: 2025-02-19
• Last Update Posted: 2025-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age from 5 to 10 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status I and II.
• Scheduled for elective surgery.

Exclusion Criteria

• Diabetes mellitus.
• Insulin resistance (IR).
• Renal or hepatic insufficiency.
• Esophageal or gastric surgery or gastrointestinal disorders history (including gastroesophageal reflux, hiatal hernia, or gastritis).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Apple juice group	Apple juice	A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml).
Anhydrous glucose group	Anhydrous glucose	A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika).
Water group	Water	Patients received water

Primary Outcome Measures

Name	Time	Method
C-reactive protein (CRP) level	4 hours postoperatively	C-reactive protein (CRP) level was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.

Secondary Outcome Measures

Name	Time	Method
Level of C-peptide	4 hours postoperatively	Level of C-peptide was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.
Neutrophil/ lymphocyte ratio	4 hours postoperatively	Neutrophil/ lymphocyte ratio (NLR) was assessed 2 h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.
Level of procalcitonin	4 hours postoperatively	Level of procalcitonin was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.
Homeostatic model assessment for insulin resistance	4 hours postoperatively	Homeostatic model assessment for insulin resistance(HOMA.IR) was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.
Level of random blood glucose	Two hours before the surgery	Level of random blood glucose (RBG) was measured at two hours before the surgery.
Patient's parent's satisfaction	4 hours postoperatively	Parent satisfaction level was evaluated by 3-point Likert scale (1, unsatisfied; 2, neutral; 3, satisfied).
Incidence of complications	4 hours postoperatively	Incidence of complications such as perioperative nausea, vomiting, and aspiration were documented.

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, El-Gharbia, Egypt