Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Measure pO2 in rectal cancers
研究概览
简要总结
The purpose of this study is to see if the cells in rectal cancer are oxygen-starved, or hypoxic. We know that as cancers grow bigger, parts of them are cut off from the oxygen supply and they become hypoxic, basically, lacking oxygen. Research has shown that cells that are oxygen-starved respond differently to treatment such as chemotherapy and radiation when compared to cells that are oxygen rich.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biopsy proven adenocarcinoma of the rectum. If a biopsy was taken at an outside hospital, the slides and diagnosis will be reviewed and confirmed by a pathologist at MSKCC.
- •Mid to distal rectal tumors not requiring pre-op radiation or chemotherapy
- •Age < 90
- •Karnofsky performance status ≥ 60
- •Ability to understand and the willingness to sign a written informed consent document.
排除标准
- •Current pregnancy
- •Uncontrolled intercurrent illness that would limit compliance with study requirements.
研究组 & 干预措施
pO2 measurements
In patients meeting eligibility requirements outlined below, comparisons will be made between direct pO2 measurements using a tissue hypoximeter and IHC-assessed expression of hypoxia related proteins (HIF-1α, VEGF, CA IX and GLUT-1) in both normal and tumor tissue.
干预措施: Eppendorf hypoximeter (Procedure)
结局指标
主要结局
Measure pO2 in rectal cancers
时间窗: 2 years
Measure pO2 in rectal cancers
次要结局
- Correlate immunohistochemical analysis of endogenous markers of hypoxia(2 years)