RBR-5n4htp招募中1 期
Disulfiram repurposing in the combined chemotherapy of Chagas disease – Phase I/II Clinical Trial
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Intervention
入排标准
- 年龄范围
- 18Y 至 70Y（—）
入选标准
- •Adults; aged from 18 to 70 years; both sexes; diagnosis of chronic Chagas disease in the indeterminate form or cardiac form at stage A; two distinct serological tests (enzyme-linked immunosorbent assay and indirect immunofluorescence or chemiluminescence) positive for Chagas disease
排除标准
- •Previous benznidazol (BZ) or dissulfiram (DF) treatment, contraindications or hypersensitivity; alcoholism; smoking; renal or hepatic impairment; gastrointestinal disorders; pulmonary, epileptic, haematological disorders; pregnancy or lactation; heart disease associated with moderate or severe orovalvar disease, ischemic, congenital or hypertensive heart disease; systemic diseases such as autoimmune disorders, cancer, other infectious diseases such as acquired immunodeficiency syndrome; use of 3 or more regular medications within 2 weeks before starting study treatment except for contraceptive (for women), omeprazol and sinvastatin; use of any eventual medication within 7 days before starting study treatment; use of any antifungal 60 days before starting study treatment; previous intervention studies one year before; severe cognitive impairments
研究者
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