Effects of Inspiratory and Expiratory Pressure Training Methods in Patients With Chronic Obstructive Pulmonary Disease

Not Applicable

• Conditions: Chronic Obstructive Pulmonary Disease(COPD)
• Interventions: Device: inspiratory pressure training group; Device: mixed training group

• Registration Number: NCT02326181
• Lead Sponsor: Zhujiang Hospital

Brief Summary

The study will investigate the effects of different training types ,including combined inspiratory with expiratory pressure threshold training,inspiratory pressure threshold training on patients with chronic obstructive airway disease and investigate whether expiratory pressure threshold training associated with inspiratory pressure threshold training would be better than inspiratory pressure threshold training alone, with regard to exercise capacity, respiratory muscle strength and endurance.

Detailed Description

We will study 60 patients diagnosed of chronic obstructive pulmonary disease.The monitoring will be done for 8 weeks. Pressure-threshold respiratory trainers were calibrated to provide different loads according to the patients against inspiration (IMST) or expiration (EMST). Those chronic obstructive pulmonary disease clinically stable patients stratified from mild to very severe GOLD stages, were blinded to randomly divided into 3 different groups: a)control group:without any training;b) inspiratory and expiratory pressure threshold training group: trained with the pressure threshold trainer twice time daily with 15minutes' duration;c)inspiratory pressure threshold training group:trained with the pressure threshold trainer twice time daily with 15 minutes' duration,different from the b group,the expiratory pressure threshold is calibrated at 0.

Study Timeline

• Status Verified: 2014-12
• Study First Submitted: 2014-12-21
• Study First Submitted QC: 2014-12-24
• Last Update Submitted: 2014-12-24
• Study First Posted: 2014-12-25
• Last Update Posted: 2014-12-25
• Study Start: 2015-01
• Primary Completion: 2016-12
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Clinically stable COPD with diagnosis of forced expiratory volume at one second(FEV1)/forced vital capacity(FVC) < 70%

Exclusion Criteria

Cancer Unstable heart disease Neuromusculoskeletal disorder mental disorder Active smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
inspiratory pressure training group	inspiratory pressure training group	The patients will perform daily in 2 sessions of 30 minutes, using a pressure threshold trainer.
mixed training group	mixed training group	The patients will perform daily in 2 sessions of 30 minutes, using a pressure threshold trainer.

Primary Outcome Measures

Name	Time	Method
respiratory muscle strength measurements	baseline and 8 weeks

Secondary Outcome Measures

Name	Time	Method
perceived exertion for leg fatigue (Borg-scale)	baseline and 8 weeks
respiratory muscle endurance text	baseline and 8 weeks
6-minute walking test	baseline and 12 weeks
modified british medical research council(mMRC) questionnaire	baseline and 8 weeks

Trial Locations

Locations (1)

Zhujiang hospital; 🇨🇳 Guangzhou, Guangdong, China