The effect and comparison of oral and intravenous Acetaminophen in pain cardiac surgery patients
Phase 2
- Conditions
- Coronary and valvular heart surgery.Other functional disturbances following cardiac surgery
- Registration Number
- IRCT2016022026217N2
- Lead Sponsor
- Vice Chancellor for research, Lorestan University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
all patients who underwent CABG surgery with or without valve replacement; age older than 18 or less than 65 years; absence of addiction to drugs or alcohol; absence of allergy or hypersensitivity to acetaminophen or narcotics; absence of impaired kidney function (creatinine level Less than 2 milligrams per deciliter); no history of liver failure; no history of sleep apnea. Exclusion criteria: Visual analog scale score is higher than 7 after extubation; not wanting to continue cooperation?; use of narcotic drugs and sedatives during the procedure?; decreased level of consciousness of the patient during the study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of pain. Timepoint: Minute 0, 20, 80 and 120 after receiving the first dose. Method of measurement: visual analog scale.;The amount of narcotic. Timepoint: 24 hours after receiving the first dose. Method of measurement: Milligrams per kilogram of body weight.
- Secondary Outcome Measures
Name Time Method The best pattern of use drug on regular basis or on when necessary. Timepoint: 24 hours after receiving the first dose. Method of measurement: Visual anlog scale and milligrams per kilogram of body weight.;Nausea. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: history taking from patient or nurses.;Vomiting. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: history taking from patient or nurses.;Need for antiemetics. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: information taken from patient's records.