CTRI/2025/10/096024尚未招募Phase 3 4
A randomized controlled trial comparing the weaning success in mechanically ventilated patients meeting RSBI and clinical criteria with and without diaphragm ultrasonography (DUS)
Igmc shimla1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2025年10月30日最近更新:
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Weaning success is better in patients meeting Rapid shallow breathing index(RSBI) and clinical criteria with diaphragm ultrasonography (DUS)
研究概览
简要总结
Weaning patients from ventilation has always been a challenging task and wearing failure , re intubation are associated with increased risk of morbidity and mortality.
Diaphragm is the major respiratory muscle and its proper functioning is necessary for spontaneous breathing
Considering diaphragm excursion and diaphragm thickness fraction along with clinical criteria and RSBI before weaning patients from ventilator has proven to decrease re intubation rates in some studies
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients admitted in GICU of dept.
- •of Anaesthesia IGMC Shimla and are on mechanical ventilator with following parameters
- •Normal performance status before disease onset ( per- illness frailty score less than 3)
- •Who are mechanically ventilated for at lest 24 h
- •With satisfactory clinical weaning parameters such as the ability to tolerate a spontaneous breathing trial (SBT) for 1 h
- •Stable haemolytic or on minimal and single vasopressin ,afebrile in the last 24 hours, with minimal tracheo bronchial secretions and effective cough response will be invluded.
排除标准
- •Patient with neuromuscular disorder
- •Patient with pneumothorax
- •Preexisting diaphragmatic palsy
- •Who underwent thoracic and abdominal surgeries
- •Where ultrasound is not possible due to wound dressings.
结局指标
主要结局
Weaning success is better in patients meeting Rapid shallow breathing index(RSBI) and clinical criteria with diaphragm ultrasonography (DUS)
时间窗: To check for reintegration rate within 24 hours
次要结局
未报告次要终点
研究者
Dr Ajay Sood
IGMC Shimla
研究点 (1)
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