ISRCTN63226989CompletedNot Applicable
The dopaminergic system in patients with functional dyspepsia analyzed by an alpha-methyl-para-tyrosine (AMPT) challenge test and single photon emission computed tomography (SPECT) imaging before and after treatment with amitriptyline
Academic Medical Center (AMC), Department of Gastroenterology (The Netherlands)0 sites60 target enrollmentStarted: June 7, 2006Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Age 18-65 years
- •2. Functional dyspepsia (Nepean dyspepsia index [NDI] >25)
- •3. Take part in the amitriptyline study (ISRCTN76116512)
- •4. No effect on proton pump inhibitor (PPI), or a constant three-month dosage of PPI
- •5. No depression (Zung self-rating depression scale <50)
- •6. No medications which influence the intestine
Exclusion Criteria
- •1. Gastroduodenal surgery
- •2. Reflux-like dyspepsia (Rome II criteria)
- •3. Use of antidepressants
- •4. Organic abnormalities
- •5. Pregnancy
- •6. Severe cardiac, renal, pulmonary, hepatic or systemic diseases, hyperthyroidism, glaucoma and epilepsy
- •7. Metal implants
Investigators
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