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Clinical Trials/ISRCTN63226989
ISRCTN63226989
Completed
Not Applicable

The dopaminergic system in patients with functional dyspepsia analyzed by an alpha-methyl-para-tyrosine (AMPT) challenge test and single photon emission computed tomography (SPECT) imaging before and after treatment with amitriptyline

Academic Medical Center (AMC), Department of Gastroenterology (The Netherlands)0 sites60 target enrollmentJune 7, 2006
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ConditionsFunctional dyspepsia (FD)Digestive SystemDyspepsia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Functional dyspepsia (FD)
Sponsor
Academic Medical Center (AMC), Department of Gastroenterology (The Netherlands)
Enrollment
60
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
June 7, 2006
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Academic Medical Center (AMC), Department of Gastroenterology (The Netherlands)

Eligibility Criteria

Inclusion Criteria

  • •1\. Age 18\-65 years
  • •2\. Functional dyspepsia (Nepean dyspepsia index \[NDI] \>25\)
  • •3\. Take part in the amitriptyline study (ISRCTN76116512\)
  • •4\. No effect on proton pump inhibitor (PPI), or a constant three\-month dosage of PPI
  • •5\. No depression (Zung self\-rating depression scale \<50\)
  • •6\. No medications which influence the intestine

Exclusion Criteria

  • •1\. Gastroduodenal surgery
  • •2\. Reflux\-like dyspepsia (Rome II criteria)
  • •3\. Use of antidepressants
  • •4\. Organic abnormalities
  • •5\. Pregnancy
  • •6\. Severe cardiac, renal, pulmonary, hepatic or systemic diseases, hyperthyroidism, glaucoma and epilepsy
  • •7\. Metal implants

Outcomes

Primary Outcomes

Not specified

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