Prevalence of Non-alcoholic Fatty Liver Disease Among Non-obese Obstructive Sleep Apnea by Using Transient Elastography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Number of subjects found to have fatty liver disease among obese patients with obstructive sleep apnea
研究概览
简要总结
Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively. Though studies show OSA may take part in the progression of hepatic steatosis, the independent contribution of OSA on liver fat accumulation is unknown. It is hypothesized that nocturnal intermittent hypoxia from OSA is the main driver of NAFLD in non-obese OSA patients. This study is to assess the effect of OSA on NAFLD in non-obese patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18 years or more
排除标准
- •underlying cause of liver disease
- •history of excessive alcoholic consumption (more than 30 g/day for men and 20 g/day for women)
- •secondary causes of hepatic steatosis (such as chronic use of systemic corticosteroids)
- •positive hepatitis B surface antigen, anti-hepatitis C virus antibody, or histological evidence of other concomitant chronic liver diseases.
结局指标
主要结局
Number of subjects found to have fatty liver disease among obese patients with obstructive sleep apnea
时间窗: baseline
Number of subjects found to have fatty liver disease among non-obese patients with obstructive sleep apnea
时间窗: baseline
次要结局
- Number of subjects found to have fatty liver disease among obese subjects without obstructive sleep apnea(baseline)
- Number of subjects found to have fatty liver disease among non-obese subjects without obstructive sleep apnea(baseline)
- mesenteric fat thickness by ultrasound scan of all subjects(baseline)
研究者
Prof David Shu Cheong Hui
Professor
Chinese University of Hong Kong