Prevalence of Non-alcoholic Fatty Liver Disease Among Non-obese Obstructive Sleep Apnea by Using Transient Elastography

Recruiting

• Conditions: Sleep Apnea, Obstructive; Fatty Liver

• Registration Number: NCT05351515
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively. Though studies show OSA may take part in the progression of hepatic steatosis, the independent contribution of OSA on liver fat accumulation is unknown. It is hypothesized that nocturnal intermittent hypoxia from OSA is the main driver of NAFLD in non-obese OSA patients. This study is to assess the effect of OSA on NAFLD in non-obese patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-04-14
• Study First Submitted QC: 2022-04-25
• Study First Posted: 2022-04-28
• Study Start: 2022-04-30
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-29
• Last Update Posted: 2023-08-30
• Primary Completion: 2025-01-31
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• aged 18 years or more

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Exclusion Criteria

• underlying cause of liver disease
• history of excessive alcoholic consumption (more than 30 g/day for men and 20 g/day for women)
• secondary causes of hepatic steatosis (such as chronic use of systemic corticosteroids)
• positive hepatitis B surface antigen, anti-hepatitis C virus antibody, or histological evidence of other concomitant chronic liver diseases.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of subjects found to have fatty liver disease among obese patients with obstructive sleep apnea	baseline
Number of subjects found to have fatty liver disease among non-obese patients with obstructive sleep apnea	baseline

Secondary Outcome Measures

Name	Time	Method
Number of subjects found to have fatty liver disease among obese subjects without obstructive sleep apnea	baseline
Number of subjects found to have fatty liver disease among non-obese subjects without obstructive sleep apnea	baseline
mesenteric fat thickness by ultrasound scan of all subjects	baseline

Trial Locations

Locations (1)

Chinese University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong