Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population

Completed

• Conditions: Atrial Fibrillation; Nonalcoholic Fatty Liver Disease; Cross-sectional Study

• Registration Number: NCT03366987
• Lead Sponsor: Ningbo No. 1 Hospital

Brief Summary

Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There is rare research performed among elderly adults. The investigators are conducting a cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease in an elderly Chinese population.

Detailed Description

Because of the aging population and improvements in cardiovascular treatments, its prevalence is expected to increase substantially over the next few decades. AF has been reported to be associated with high rates of hospitalization and death. Along with older age, there are many independent risk factors for AF like obesity, hypertension, diabetes, ischemic heart disease, heart failure and valvular heart disease.

Non-alcoholic fatty liver disease is one of the most prevalent liver diseases in the world whose prevalence ranges from 6% to 35%, with a median of 20% in the general population. In recent years, an increasing body of evidence have indicated that NAFLD is linked to cardiovascular disease, myocardial abnormalities, left ventricular diastolic dysfunction, heart failure, aortic valve sclerosis and so on.

NAFLD has also been observed to be significantly associated with AF in patients with type 2 diabetes. Furthermore, a cohort study showed that NAFLD was associated with an increased risk of prevalent AF in a middle-aged population. However, whether the association between NAFLD and AF also holds true in the elderly population remains uncertain. Therefore, the investigators conducted this cross-sectional study to explore the association between NAFLD and AF in an elderly Chinese population.

Study Timeline

• Study First Submitted: 2017-10-26
• Study First Submitted QC: 2017-12-03
• Study First Posted: 2017-12-08
• Study Start: 2017-12-12
• Primary Completion: 2018-01-18
• Study Completion: 2018-01-30
• Status Verified: 2018-07
• Last Update Submitted: 2019-06-20
• Last Update Posted: 2019-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• those who undergone an annual physical examination at Zhenhai Lianhua Hospital, Ningbo, China in 2014
• elderly adults (≥65 years old)

Exclusion Criteria

• unknown alcohol intake or excessive alcohol intake
• unknown BMI or BMI≤18.0kg/m2
• incomplete basic physical data
• missing liver ultrasonic diagnosis
• unknown causes of chronic liver disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association of nonalcoholic fatty liver disease and atrial fibrillation	the physical examination data in the year of 2014	The association of nonalcoholic fatty liver disease and atrial fibrillation by chi-square test.

Secondary Outcome Measures

Name	Time	Method
Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration	the physical examination data in the year of 2014	Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration by chi-square test.
Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration	the physical examination data in the year of 2014	Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration by chi-square test.

Trial Locations

Locations (1)

Ningbo NO.1 hospital; 🇨🇳 Ningbo, Zhejiang, China