Association of Non-alcoholic Fatty Liver Disease and Coronary Artery Disease

Not Applicable

• Conditions: Nonalcoholic Steatohepatitis (NASH)

• Registration Number: NCT01638832
• Lead Sponsor: Johann Wolfgang Goethe University Hospital

Brief Summary

This study will evaluate the association of non-alcoholic fatty liver disease and coronary artery disease. All patients presenting for coronary angiogram will receive the following examination:

* Transient Elastography and Controlled Attenuation Parameter using the FibroScan

* blood examination including biochemical markers The results of non-invasive liver steatosis and fibrosis measurement are compared with the results of coronary angiogram concerning the presence or absence of coronary artery disease.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-06
• Study Start: 2012-06
• Study First Submitted: 2012-07-05
• Study First Submitted QC: 2012-07-11
• Last Update Submitted: 2012-07-11
• Study First Posted: 2012-07-12
• Last Update Posted: 2012-07-12
• Primary Completion: 2013-09
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 572

Inclusion Criteria

• Male or female, 18 years and older
• Written consent
• Coronary angiogram planned

Exclusion Criteria

• Patients with mental diseases
• Pregnancy or lactation
• Ascites

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Liver fibrosis scores I-IV (METAVIR)		METAVIR fibrosis scores: I = mild fibrosis II = significant fibrosis III = advanced fibrosis IV = cirrhosis

Secondary Outcome Measures

Name	Time	Method
Steatosis fibrosis scores I-III		Steatosis scores: 0 = \<5% I = 5-33% II = 33-66% III = \>66%

Trial Locations

Locations (1)

Klinikum der J. W. Goethe-Universität; 🇩🇪 Frankfurt am Main, Germany