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Clinical Trials/NCT00591994
NCT00591994
Completed
Not Applicable

Tinnitus Treatment With Piribedil Guided by Acoustic Otoemissions and Electrocochleography

Faculdade de Medicina de Valenca1 site in 1 country100 target enrollmentNovember 2006
ConditionsTinnitus

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Tinnitus
Sponsor
Faculdade de Medicina de Valenca
Enrollment
100
Locations
1
Primary Endpoint
THI - Tinnitus Handicap Inventory
Status
Completed
Last Updated
18 years ago

Overview

Brief Summary

Tinnitus is defined as the perception of sound in the absence of a external source. About 15 % of the population is believed to experience tinnitus and for about 20 % of them it may become a very serious problem. Total comprehension of tinnitus pathophysiology has not yet been achieved, but modern theories focus in brain hyperactivity following inner ear damage, with involvement of various neurotransmitters. Piribedil,a dopamin agonist, has been used to treat tinnitus, focusing in dopamine release, which is inhibitory. Electrophysiological methods,like acoustic otoemissions and electrocochleography may reveal the changes in peripherical and central auditory pathways and help to choose the specific patients who could benefit from piribedil treatment.

Registry
clinicaltrials.gov
Start Date
November 2006
End Date
December 2007
Last Updated
18 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Faculdade de Medicina de Valenca

Eligibility Criteria

Inclusion Criteria

  • tinnitus for more than 6 months
  • THI \> 38
  • no central acting drugs in the last 6 months
  • tympanogram type A-n

Exclusion Criteria

  • vascular and muscular tinnitus
  • concomitant TMJ disorders
  • abnormal otoscopy
  • mixed and conductive hearing losses

Outcomes

Primary Outcomes

THI - Tinnitus Handicap Inventory

Time Frame: Months 3 and 6

Secondary Outcomes

  • VAS - Visual Analog Scale(Months 3 and 6)

Study Sites (1)

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