Frailty in Older HIV-infected Individuals in Hong Kong: Risk Factors and Association With Quality of Life and Mortality
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Frailty
研究概览
简要总结
Frailty has been proposed as a measure of biological (as opposed to chronological) aging. In this study the investigators plan to: (1) measure frailty in a cohort of older HIV-infected individuals in Hong Kong, and its association with mortality and quality of life; (2) identify risk factors predictive of development of frailty in HIV-infected individuals in Hong Kong; and (3) determine the outcomes of HIV-infected individuals in Hong Kong with and without frailty.
The following assessment will be done:
- Physical examination including measuring height, weight, hip and waist circumference.
- Grip strength, chair stand test, gait speed test, balance tests, and neurocognitive tests
- Geriatric syndromes, screening for depression, disability and quality of life.
- Blood tests during fasting state to measure metabolic parameters.
This is a prospective longitudinal observational study that lasts for 10 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV infection with positive anti-HIV antibody
- •Age ≥50 years
排除标准
- •Refuses to consent
结局指标
主要结局
Frailty
时间窗: 10 years
Frailty defined by frailty phenotype measurement, according to Fried (Fried et al., 2011) definition.
次要结局
未报告次要终点
研究者
Grace Lui
Clinical Assistant Professor
Chinese University of Hong Kong