The Effect of Beta-Alanine and Carnosine From Beef Intake on Muscle Fatigue in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change in 6-minute walk
研究概览
简要总结
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are:
AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet.
AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue.
Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 60-85 years
- •Ability to eat study diet meals for a total of 16 weeks
- •Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire
- •Ability to provide fasted blood samples
- •Access to transportation
- •Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period
- •Ability to consent to participating in this study
- •English-speaking
- •Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2
- •Minimum total body weight of 110 pounds
- •Non-anemia hemoglobin values: Females - >12.0 grams/dL; Men - >13.0 grams/dL
- •Able to ambulate without assistance
- •Physician's clearance for study participation (required prior to baseline testing)
排除标准
- •Inability or refusal to sign the informed consent
- •Significant orthopedic limitations or other contraindications to exercise
- •Inability or refusal to perform muscle fatigue tests
- •Has dietary restrictions that prevent to consumption of beef, soy and/or wheat
- •Has liver or kidney complications
- •Live or work >25 miles from Bloomington study site or does not have transportation to the study site
- •Anticipate elective surgery during the study period
- •Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis
- •Fracture or serious injury in the last 6 months
- •Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months
- •Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease
- •Plan to move residence or travel out of the local area during the study period
- •Current use of anti-coagulants (e.g. Coumadin or Warfarin)
- •Current use of prescription medications that affect heart rate or blood vessel dilation
- •Psychological or social characteristics that would interfere with their ability to fully participate in the study
研究组 & 干预措施
Beef Diet
Participants will be randomized to consume the beef diet for 8 weeks. After a 2-week period, participants will cross-over to consume the vegetarian diet for 8 weeks.
干预措施: Beef Diet (Other)
Vegetarian Diet
Participants will be randomized to consume the vegetarian diet for 8 weeks. After a 2-week period, participants will cross-over to consume the beef diet for 8 weeks.
干预措施: Vegetarian Diet (Other)
结局指标
主要结局
Change in 6-minute walk
时间窗: Weeks 0, 4, 8
The change in muscle strength observed in each diet condition will be evaluated through the 6-Minute-Walk-Test. The distance walked by a participant during the 6 minute test period will be recorded.
Adherence to Study Diets
时间窗: Through study completion, approximately 16 weeks
Participant adherence to the study diets will be evaluated.
Change in Sit-to-Stand Chair Test
时间窗: Weeks 0, 4, 8
The change in muscle strength observed in each diet condition will be evaluated through the Sit-To-Stand Chair Test. The number of times a participant comes to a full standing position (from a seated position) in 60 seconds will be recorded.
Retention of Participants
时间窗: Through study completion, approximately 16 weeks
The percentage of randomized participants completing the 16-week diet intervention trial.
次要结局
- Change in Amino Acids(Weeks 0, 4, 8)
- Change in Lactate(Weeks 0, 4, 8)
- Change in Carnosine(Weeks 0, 4, 8)
- Change in Beta-Alanine(Weeks 0, 4, 8)
研究者
Cydne Perry
Assistant Professor Applied Health Sciences
Indiana University