The effect of intrathecal methylprednisolone on features of central sensitization in patients with Chronic Complex Regional Pain Syndrome Type 1.

Suspended

• Registration Number: NL-OMON20155

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Suspended
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Patients will be male or female, outpatients aged 18 - 75 year, with a clinical diagnosis of CRPS who are referred to the LUMC .

1. At onset patients must fulfill the criteria for CRPS I. These criteria include the combination of continuing pain, allodynia or hyperalgesia, rendering the pain disproportionate to any inciting event, evidence at some time of edema, changes in skin blood flow, or abnormal sudomotor activity in the region of the pain, absence of a condition which would otherwise account for the degree of pain and dysfunction;

Exclusion Criteria

1. Patients are excluded if they can obtain satisfactory relief of symptoms with conventional treatments such as NSAIDs or paracetamol;

2. Patients using oral anticoagulant medication or having an impaired blood coagulation for other reasons;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The severity of spontaneous pain is evaluated through a 10 cm<br>visual-analogue scale (0 cm represents no pain, 10 cm represents the<br>worst imaginable pain). This will be filled in at home in a diary.<br /><br>Primary outcome is pain relief at 6 weeks.