The effect of added perineural methylprednisolone to peripheral nerve block combined with intravenous dexamethasone for prolonged post-discharge analgesia after fast-track total knee arthroplasty
- Conditions
- OA Knee going on total knee arthroplasty-Steroids-methylprednisolone-Peripheral nerve block- Motor-sparing nerve block-Postoperative Pain-Analgesia-Total Knee Arthroplasty
- Registration Number
- TCTR20200313006
- Lead Sponsor
- none
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 79
Patient who was scheduled for total knee arthroplasty at King Chulalongkorn Memorial Hospital ASA class 1 to 3
ASA class 1 A normal healthy patient
ASA class 2 A patient with mild systemic disease Mild diseases only without substantive functional limitations
ASA class 3 A patient with severe systemic disease but not threaten to life
Body mass index BMI between 18 to 40 kg m2
refuse to participate this study
unable to cooperate or cognitive impairment eg dementia
allergy to any drug in this study
contraindication to methylprednisolone
contraindication to neuraxial anesthesia eg coagulopathy
contraindication to NSAIDs Ketorolac and Celebrex in this study
poor controlled diabetic mellitus (HBA1C>8)
hepatic and/or renal insufficiency
chronic opioids use or diagnosed of neuropathic pain
unable to performed Time up and go test
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of moderate-severe pain through 14 day after surgery (from discharge until postoperative day 14) Percentage of NRS score 4 to 6
- Secondary Outcome Measures
Name Time Method postoperative pain score of knee pain at rest post operative day 0-14 and week 3-12 Numerical pain rating scale,postoperative pain score of knee pain on movement post operative day 0-14 and week 3-12 Numerical pain rating scale,postoperative nausea and vomitting post operative day 0-2 Visual analog scale ,quality of sleep post operative day 0-7 Likert scale,quadriceps muscle strength postoperative day 1,2 digital dynamometer,Degree of knee flexion and extension Postoperative 0, 1, 2 Days Degree of range of motion,Timed up and go test, KSS, 5 times sit to stand , 2 mins walk test Postoperative 1, 2 days and 2 , 6 weeks and 3 month Rehabilitation after surgery,Incidence of rebound pain after ACB catheter was removed percentage of NRS more than 6,Incidence of moderate-severe pain 2 weeks to 1 month and 1 month to 3 months after surgery Percentage of NRS score 4 to 6