DRKS00026205招募中未知
Predictive relevance of genetic polymorphisms in the glycogen-synthase-kinase-3beta (GSK3B) mediated intracellular signal transduction for the efficacy of lithium augmentation of antidepressants in the treatment-resistant major depression - ALIA
Charité - Universitätsmedzin Berlin0 个研究点目标入组 500 人开始时间: 2021年9月14日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 500
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •unipolar major depression
- •-indication for antidepressant pharmacotherapy
- •-HAMD-17 = 12
- •-Inadequate response to antidepressant monotherapy and indication for lithium augmentation.
- •-Minimum age: 18 years
- •-physician-confirmed capacity to consent
- •-written informed consent
- •-No participation in an AMG study (1 month prior) and during study participation.
排除标准
- •-psychotic symptoms, current
- •-Contraindication to lithium therapy (e.g. severe renal insufficiency, pathological TSH or relevant ECG changes) - for a list of contraindications, see the technical information in the appendix.
- •-laboratory values and/or ECG findings that speak against taking lithium
- •-depressive syndrome due to a non-psychiatric or in the context of a further axis I diagnosis
- •-diagnosis of dementia or organic brain disease
- •-Diagnosis of substance dependence and use of the substance in the last 6 months (except caffeine and nicotine)
- •-Diagnosis of an antisocial personality disorder
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