DRKS00026205
Recruiting
未知
Predictive relevance of genetic polymorphisms in the glycogen-synthase-kinase-3beta (GSK3B) mediated intracellular signal transduction for the efficacy of lithium augmentation of antidepressants in the treatment-resistant major depression - ALIA
Charité - Universitätsmedzin Berlin0 sites500 target enrollmentSeptember 14, 2021
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- F32
- Sponsor
- Charité - Universitätsmedzin Berlin
- Enrollment
- 500
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •unipolar major depression
- •\-indication for antidepressant pharmacotherapy
- •\-HAMD\-17 \= 12
- •\-Inadequate response to antidepressant monotherapy and indication for lithium augmentation.
- •\-Minimum age: 18 years
- •\-physician\-confirmed capacity to consent
- •\-written informed consent
- •\-No participation in an AMG study (1 month prior) and during study participation.
Exclusion Criteria
- •\-psychotic symptoms, current
- •\-Contraindication to lithium therapy (e.g. severe renal insufficiency, pathological TSH or relevant ECG changes) \- for a list of contraindications, see the technical information in the appendix.
- •\-laboratory values and/or ECG findings that speak against taking lithium
- •\-depressive syndrome due to a non\-psychiatric or in the context of a further axis I diagnosis
- •\-diagnosis of dementia or organic brain disease
- •\-Diagnosis of substance dependence and use of the substance in the last 6 months (except caffeine and nicotine)
- •\-Diagnosis of an antisocial personality disorder
Outcomes
Primary Outcomes
Not specified
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