Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
- Conditions
- Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations
- Registration Number
- NCT02849977
- Lead Sponsor
- Rhythm Pharmaceuticals, Inc.
- Brief Summary
The purpose of this screening study is to identify people who have a rare genetic cause of obesity - specifically three genetic variants (a change in the DNA structure) of the POMC, PCSK1 and LepR genes that are currently known to result in obesity.
This screening study will not include any investigational drugs. You will be asked to provide a DNA sample and answer some questions about your medical history and hunger.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5966
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of individuals with POMC, LepR or PCSK1 genetic mutations 1 Year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (57)
Axis Clinical Trails
🇺🇸Los Angeles, California, United States
PRI, LLC - Newport Beach - M3 Wake Research
🇺🇸Newport Beach, California, United States
South Florida Clinical Trials
🇺🇸Hialeah, Florida, United States
Synexus Clinical Research US, Inc. - Chicago
🇺🇸Chicago, Illinois, United States
Impact Clinical Trials - Las Vegas
🇺🇸Las Vegas, Nevada, United States
Synexus Clinical Research US, Inc. - Akron
🇺🇸Akron, Ohio, United States
Synexus Clinical Research US, Inc. - Cincinnati
🇺🇸Cincinnati, Ohio, United States
Nationwide Children's Hospital, Center for Healthy Weight and Nutrition
🇺🇸Columbus, Ohio, United States
Synexus Clinical Research US, Inc. - Columbus
🇺🇸Columbus, Ohio, United States
Synexus Clinical Research US, Inc. - Primary Care Associates
🇺🇸Anderson, South Carolina, United States
Synexus - Synexus US, LP - Dallas
🇺🇸Dallas, Texas, United States
Synexus Clinical Research US, Inc. - San Antonio
🇺🇸San Antonio, Texas, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
Tucson Neuroscience Research - M3 Wake Research
🇺🇸Tucson, Arizona, United States
Synexus Clinical Research US, Inc. - Phoenix Southeast
🇺🇸Chandler, Arizona, United States
PRI, LLC - Los Alamitos - M3 Wake Research
🇺🇸Los Alamitos, California, United States
Palm Harbor Medical Associates - BTC - PPDS
🇺🇸Palm Harbor, Florida, United States
Maine Medical Partners Pediatric Specialty Care
🇺🇸Portland, Maine, United States
Helen DeVos Children's Hospital Healthy Weight Center
🇺🇸Grand Rapids, Michigan, United States
NYU Langone Medical Center
🇺🇸New York, New York, United States
Cohen Children's Medical Center of NY
🇺🇸Lake Success, New York, United States
Columbia University
🇺🇸New York, New York, United States
Duke University Hospital
🇺🇸Durham, North Carolina, United States
University of Tennesseee Health Science Center
🇺🇸Memphis, Tennessee, United States
Vanderbilt University
🇺🇸Nashville, Tennessee, United States
Global Medical Research - M3 Wake Research
🇺🇸DeSoto, Texas, United States
University of Utah, Department of Surgery
🇺🇸Salt Lake City, Utah, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
IRCCS Istituto Auxologico Italiano
🇮🇹Oggebbio, Italy
Rabin Medical Center - PPDS
🇮🇱Petah Tikva, Israel
Hospital Senhora da Oliveira -Guimaraes, E.P.E
🇵🇹Guimarães, Portugal
Kaplan Medical Center
🇮🇱Rehovot, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Schneider Children's Medical Center of Israel - Petah Tikvah - PIN
🇮🇱Petach Tikva, Israel
Baystate Children's Hospital, Division of Pediatric Endocrinology
🇺🇸Springfield, Massachusetts, United States
Nemours Foundation Alfred Dupont Children's Hospital
🇺🇸Wilmington, Delaware, United States
Medical Research Center of Memphis, LLC - M3 Wake Research
🇺🇸Memphis, Tennessee, United States
Charite Campus Virchow-Klinikum Institute for Experimental Pediatric Endocrinology
🇩🇪Berlin, Germany
Axis Clinical Trials
🇺🇸Los Angeles, California, United States
New York Clinical Trials-Brooklyn
🇺🇸Brooklyn, New York, United States
Texas Tech University Health Sciences Center
🇺🇸Amarillo, Texas, United States
Clinical Research Advantage Inc.
🇺🇸Mesa, Arizona, United States
Synexus Clinical Research US, Inc. - St. Petersburg
🇺🇸Pinellas Park, Florida, United States
Synexus Clinical Research US, Inc. - West Florissant Internists
🇺🇸Bridgeton, Missouri, United States
Division of Endocrinology/Diabetes Amanda House
🇺🇸Buffalo, New York, United States
New York Clinical Trials-Manhattan
🇺🇸New York, New York, United States
University of Hospital of Patras
🇬🇷Patras, Greece
Synexus Clinical Research US, Inc. - Simon Williamson Clinic, PC
🇺🇸Birmingham, Alabama, United States
University of Florida
🇺🇸Gainesville, Florida, United States
Translational Research Inst. for Metabolism and Diabetes
🇺🇸Orlando, Florida, United States
Nemours Children's Hospital
🇺🇸Orlando, Florida, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
UNC Health Care - NC Children's Specialty Clinic
🇺🇸Chapel Hill, North Carolina, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Synexus Clinical Research US, Inc. - Centennial Health, PC -
🇺🇸Oklahoma City, Oklahoma, United States
University of Alberta
🇨🇦Edmonton, Alberta, Canada