OCTA in Central Serous Chorioratinopathy Treated With Oral Eplerenone or Hal-fluence Photodynamic Therapy: a Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- Study of vessel density in retinal choriocapillaris networks, using OCTA, in patients underwent half fluence photodynamic therapy and oral eplerenone
研究概览
简要总结
The study aims to analyze the changes in OCTA parameters and in choroidal thickness in patients affected by central serous chorioretinopathy treated by oral eplerenone and half-fluence photodynamic therapy.
详细描述
Central serous chorioretinopathy (CSC) is a chorioretinal disease characterized by serous detachment due to the dilatation and hyperpermeability of choroidal vessels resulting in the accumulation of serous fluid between the neurosensory retina and the retinal pigment epithelium.
Several studies reported the efficacy of half-fluence photodynamic therapy (PDT) and oral eplerenone in the CSC treatment inducing a reduction of the choroidal hyperpermeability and remodeling the choroidal vascularization.
This retrospective study aims to perform a quantitative analysis of retinal and CC vessel density by OCTA at baseline, 3 and 6 months in patients underwent PDT and patients underwent eplerenone.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age older than 30 years
- •diagnosis of central serous chorioretinopathy
- •treatment-naïve with half-fluence photodynamic therapy or oral eplerenone
- •absence of vitreoretinal and vascular retinal diseases
排除标准
- •age younger than 30 years
- •absence of diagnosis of central serous chorioretinopathy
- •previous treatment with half-fluence photodynamic therapy or oral eplerenone
- •presence of concomitant vitreoretinal and vascular retinal diseases
研究组 & 干预措施
Oral Eplerenone
Patients with central serous chorioretinopathy, treated by oral eplerenone
干预措施: Eplerenone (Drug)
Half fluence photodynamic therapy
Patients with central serous chorioretinopathy, treated by half-fluence photodynamic therapy
干预措施: The patients underwent half fluence photodynamic therapy for 6 months (Device)
结局指标
主要结局
Study of vessel density in retinal choriocapillaris networks, using OCTA, in patients underwent half fluence photodynamic therapy and oral eplerenone
时间窗: 6 months
To evaluate the role of optical coherence tomography angiography in predicting the changes of the vessel density of retinal and choriocapillaris vascular networks , comparing patients underwent half-fluence phodynamic therapy and patients with oral eplerenone. The vessel density are expressed as percentage
次要结局
未报告次要终点
研究者
Gilda Cennamo
Principal Investigator
Federico II University