Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs

Completed

• Conditions: Thrombosis

• Registration Number: NCT01878916
• Lead Sponsor: Istanbul University

Brief Summary

Hyperhomocysteinemia is a risk for thrombosis. Thrombosis is more frequent in myeloproliferative neoplasms (MPNs) than the normal population. In this study, we investigated the thrombosis incidence, the effects of plasma homocysteine levels on thrombosis, and the correlations between folate, cobalamin, pyridoxine and homocysteine levels in MPNs, and to compare these results with the healthy controls.

Detailed Description

Thirty-one new or formerly diagnosed MPN patients who consecutively visitted our outpatient clinic, as well as 40 age and sex matched healthy controls were enrolled in this study.

Study Timeline

• Study Start: 2003-01
• Primary Completion: 2004-06
• Study Completion: 2004-06
• Study First Submitted: 2013-05-29
• Status Verified: 2013-06
• Study First Submitted QC: 2013-06-14
• Last Update Submitted: 2013-06-14
• Study First Posted: 2013-06-17
• Last Update Posted: 2013-06-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Adult MPN patients and healthy controls who gave a written consent were included in the study.

Exclusion Criteria

Exclusion criteria included not giving a written consent and using medications without an indication which may have an effect on plasma homocysteine and vitamin levels.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thrombosis	at least 1 year

Secondary Outcome Measures

Name	Time	Method
High Hcy level	1 year

Trial Locations

Locations (1)

Istanbul University Cerrahpasa Medical Faculty; 🇹🇷 Istanbul, Turkey