The Influence of Physical Training in Normobaric Hypoxia on Prooxidant-Antioxidant Imbalance, Inflammatory Marker Levels, Intestinal Damage Degree, and Mitochondrial Energy Release Rate in Young Non-trained Males
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 2
- Primary Endpoint
- Blood analysis
Study Overview
Brief Summary
- Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.
- Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 19 Years to 29 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.
Exclusion Criteria
- •changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.
Outcomes
Primary Outcomes
Blood analysis
Time Frame: 7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.
Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes).
Measurement of aerobic capacity (endurance)
Time Frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks.
Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)
Measurement of anaerobic capacity
Time Frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks
Measurement of maximal anaerobic power (Wingate Anaerobic Test)
Somatic indices
Time Frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks.
Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\]
Secondary Outcomes
No secondary outcomes reported