Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate as an Indicator for Detecting Intravascular Injection of Epinephrine Containing Test Dose During Operation in Anesthetized Adults
概览
- 阶段
- 不适用
- 干预措施
- Epinephrine
- 疾病 / 适应症
- Injections, Intravenous
- 发起方
- Seoul National University Hospital
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- change of perfusion index from baseline
- 最后更新
- 15年前
概览
简要总结
The purpose of this study is to determine whether changes in perfusion index can be used for detecting intravascular injection of an epinephrine in anesthetized adults and to compare its reliability with criteria using changes in heart rate, systolic blood pressure or T-wave amplitude.
详细描述
Intravenous injection of local anesthetics could result in life-threatening complications during general anesthesia. Physicians usually use local anesthetics containing epinephrine to detect intravascular injection. Existing methods including heart rate, systolic blood pressure and T-wave amplitude are unreliable to detect intravascular injection during anesthesia and a method using changes in perfusion index was recently suggested. This study was designed to determine whether perfusion index is a reliable method to detect intravascular injection of epinephrine containing local anesthetics and to compare its reliability with conventional criteria in sevoflurane anesthetized adults. We will randomize patients to 2 groups: a saline group and an epinephrine group. Changes in perfusion index, systolic blood pressure, heart rate and T-wave amplitude will be measured during 5 minutes after injection of 3 mL of saline or 1% lidocaine containing epinephrine. we will determine sensitivity, specificity, positive predictive value and negative predictive value.
研究者
入排标准
入选标准
- •ASA physical status 1 patients undergoing general anesthesia for elective surgery
排除标准
- •emergent operation
- •those who are taking anticoagulant medication, calcium channel blockers, or b-blockers
- •laparoscopic operation
- •history of smoking
研究组 & 干预措施
Epinephrine
干预措施: Epinephrine
Control
干预措施: Control
结局指标
主要结局
change of perfusion index from baseline
时间窗: during 5 min after injection of epinephrine containing test dose or saline
we will observe the change of perfusion index from baseline during 5 min after injection of epinephrine containing test dose or saline. Patients whose perfusion index decrease more than 25% are defined as positive response.we will obtain the sensitivity, specificity, positive predictive value, negative predictive value using perfusion index criteria to determine the reliability of perfusion index criteria.
次要结局
- change of systolic blood pressure, heart rate, T-wave amplitude from baseline(during 5 min after injection of epinephrine containing test dose or saline)