Assessment And Comparison of The Association of Diaphragmatic Thickness Fraction and Parasternal Intercostal Muscle Thickness Fraction With Weaning Failure from Mechanical Ventilation.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Weaning Success:
研究概览
简要总结
This prospective, observational cohort study at Holy Family Hospital, New Delhi will evaluate weaning readiness in ICU patients on mechanical ventilation for over 24 hours. After ethical approval and informed consent, eligible patients will undergo assessments, including diaphragm thickness and intercoastal muscle measurements, using ultrasound during a spontaneous breathing trial (SBT). Diaphragm thickening fraction (TFdi) and intercostal muscle thickening fraction (TFic) will be calculated. The Rapid Shallow Breathing Index (RSBI) will also be recorded. Treating intensivists, blinded to these findings, will make extubation decisions, with weaning success defined as sustained extubation without support for 48 hours.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Age more than 18 years 2.Patients on mechanical ventilation for more than 24 hours.
- •3.Fulfilling weaning criteria 4.Adequate cough, absence of excessive tracheobronchial secretion, resolution of underlying critical illness for which the patient is intubated 5.The patient is alert and cooperative, without sedation.
排除标准
- •1.History of diaphragm paralysis, spinal cord injury higher than T8 2.Chronically on domiciliary BiPAP support 3.Neuromuscular diseases, 4.Pregnancy 5.Pneumothorax, pneumomediastinum, thoracostomy, chest tube or chest injuries that prevent ultrasound 6.Pleural lesions or pleurodesis 7.Previous history of failed extubation or weaning.
- •Left ventricular ejection fraction less than 40% 9.H/o Chronic lung disease with cor pulmonale (Interstitial Lung disease, Chronic Obstructive Pulmonary Disease).
结局指标
主要结局
Weaning Success:
时间窗: Within 48 hours post-extubation.
Successful extubation with no need for ventilatory support within 48 hours post-extubation.
时间窗: Within 48 hours post-extubation.
次要结局
未报告次要终点
研究者
Dr Sumit Ray
Holy Family Hospital