Identification and Impact of Vaginal Flora Anomalies Among Pregnant Woman
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,000
- 试验地点
- 12
- 主要终点
- identification and quantification by molecular biology of lactobacilla and all the other micro-organisms involved in vaginal flora anomalies
研究概览
简要总结
This is a prospective multicentric study including six clinical units of Gynecology and Obstetrics (5 public health hospital and one private team), one research team in clinical microbiology and one Center of Clinical investigation (CIC).
There is a correlation between premature delivery and bacterial vaginosis. So, the anomalies of vaginal flora are a potential target for the campaign against prematurity.
The main objective of this study is to achieve an objective and reproducible technique of identification and quantification by molecular biology of lactobacilla and all the other micro-organisms involved in vaginal flora anomalies.
The secondary objectives are the exhaustive culture of bacteria, the characterisation of intermediate vaginal flora and bacterial vaginosis among pregnant woman by PCR targeting the ribosomic ADN 16S coupled with clonage techniques.
The number of patient to include is 1000 (time of inclusions: 24 months). The vaginal smears will be realized until 32 weeks of gestation (Max: 3 taking of vaginal smears by patient).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant patients aged more than 18 years and more than 14 weeks of gestation but less than 28 weeks.
- •Multiple pregnancy won't be included.
- •Patient with a risk of premature delivery with a short cervix or a cervix measured at less than 25 mm (measure done by vaginal ultrasound of the cervix).
- •Or patient with a past of premature delivery and/or of late abortion.
- •Symptomatic or asymptomatic patient.
- •Patients consulting for pregnancy follow up or hospitalized in a unit of Gynecology and Obstetrics involved in the study.
- •social security cover
- •written informed consent
排除标准
- •antecedents : treated hypertension, Foetal malformation, APLS known, diabetes, renal disease, SLE
- •treated with antibiotics the inclusion's day
- •dropping consent.
结局指标
主要结局
identification and quantification by molecular biology of lactobacilla and all the other micro-organisms involved in vaginal flora anomalies
时间窗: 24 months
次要结局
未报告次要终点